Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
Status:
Completed
Trial end date:
2006-08-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to assess the comparative utility of topical formulations in
hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm
diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using
a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K,
1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per
subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist
rated bruises in standardized photographs immediately after bruise creation and at week 2.
Phase:
N/A
Details
Lead Sponsor:
Northwestern University
Treatments:
Petrolatum Retinol palmitate Vitamin A Vitamin K Vitamins