Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising

• Status: Completed
• Trial end date: 2006-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Northwestern University
• Treatments: Petrolatum; Retinol palmitate; Vitamin A; Vitamin K; Vitamins

Criteria

Inclusion Criteria:

• Age 20-60

• Subjects are in good health.

• Subjects have willingness and the ability to understand and provide informed consent for participation in the study.

Exclusion Criteria:

• Subjects who are currently using any anticoagulation therapy (Warfarin, Heparin, Aspirin)

• Subjects who have a history of bleeding disorders.

• Subjects who are unable to understand the protocol or to give informed consent

• Subjects with mental illness

• Subjects who are pregnant or nursing.

• Subjects who have active systemic or local infection

• Subjects with systemic or local skin disease.

• Subjects with systemic illness.