Effects of Topical Insulin on Levels of Tear Inflammatory Mediators

• Status: Recruiting
• Trial end date: 2022-01-26
• Target enrollment: 0
• Participant gender: All

Summary

60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universiti Kebangsaan Malaysia Medical Centre
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• all diabetics aged 18 - 50 years of age with at least mild OSDI scores

Exclusion Criteria:

• Diabetics on contact lenses

• Diabetic with history of ocular surgery in the preceding 3 months

• Post menopausal women

• Known mild dry eye with prior usage of topical therapy who are unable to discontinue

• Known case of allergic eye disease

• Sjogren's syndrome patients

• Unwilling or unable to attend 6 follow up and sampling sessions