Effects of Sulforaphane on Normal Prostate Tissue

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The investigators proposed to identify the biological effects of a high-sulforaphane broccoli sprout extract in normal prostate tissue.

The investigators hypothesize that consumption of high-sulforaphane broccoli sprout extract every other day will inhibit growth of prostate cancer cells.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fred Hutchinson Cancer Research Center
• Collaborators: Cedars-Sinai Medical Center; Johns Hopkins University; Seattle Institute for Biomedical and Clinical Research; University of Washington; VA Puget Sound Health Care System
• Treatments: Sulforafan; Sulforaphane

Criteria

Inclusion Criteria:

• Men aged 40-75 years

• Low or intermediate grade prostate cancer (as defined by Gleason sum less than or equal to 7) and clinical stage T1 or T2

• Serum Prostate specific antigen less than 20 ng/ml

• Have elected radical prostatectomy, Brachytherapy or active surveillance as their primary treatment

Exclusion Criteria:

• No current physician diagnosed disease (including but not limited to): kidney disease requiring dialysis, cognitive deficits, substance abuse

• BMI < 18.5 kg/m2 or > 40 kg/m2

• Use of any hormonal treatments, including but not limited to testosterone

• Any previous cancer diagnosis or treatment within the previous five years, excluding non-melanoma skin cancer

• Inability or unwillingness to eat a diet that is free of Brassica vegetables for the duration of the study

• Use of any dietary supplements other than a multivitamin (including herbal preparations)

• Allergy to cruciferous vegetables or any of the specific fillers used in the placebo

• Usual consumption of > 5 servings per week of Brassica vegetables