Effects of Subanesthetic Isoflurane/Sevoflurane in 60% Oxygen on Clinical In-vitro Experimental Sepsis
Status:
Unknown status
Trial end date:
2018-07-01
Target enrollment:
Participant gender:
Summary
Sepsis is a major cause of death in intensive care units. Despite the investigators improved
understanding, which has reduced the risk of dying with sepsis, the number of people who die
each year continues to increase due to an overall increase in the number of cases.In our
previous study, the investigators have showed that 100% oxygen or 0.5 minimum alveolar
concentration (MAC) isoflurane/sevoflurane in 60% oxygen protect mouse macrophage cell line
against in-vitro sepsis induced by lipopolysaccharide (LPS).
In this study, the investigator hypothesized that treatment of 100% oxygen or 0.5 MAC
isoflurane/sevoflurane in 60% oxygen protected against clinical in-vitro models of sepsis
induced by LPS or plasma from septic patients.
Phase:
N/A
Details
Lead Sponsor:
Air Force Military Medical University, China Fourth Military Medical University