Overview

Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Nanjing PLA General Hospital
Treatments:
Cortisol succinate
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Criteria
Inclusion Criteria:

- All patients(ageā‰§18y)

- Admitted for septic shock were considered eligible if they had no life-threatening
systemic disease (ASA groups 1~3)

Exclusion Criteria:

- Lactation

- Mental disorders

- Disseminated cancer

- Secondary cancers

- Inflammatory bowel disease, or diseases hindering epidural analgesia