Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
Status:
Not yet recruiting
Trial end date:
2024-06-15
Target enrollment:
Participant gender:
Summary
This study will enroll patients meeting Diagnostic and Statistical Manual of Mental
Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD).
Following an initial screening visit, clinical assessment, and enrollment, subjects will be
randomized into treatment and placebo arms. Both cohorts will undergo a pre-intervention
functional magnetic resonance imaging (fMRI) of their brain. Treatment subjects will receive
unilateral two-level stellate ganglion block via ultrasound-guided injection of anesthetic
(bupivacaine) into the cervical sympathetic tissue; placebo subjects will receive an
identical volume of saline via the same procedures.
At approximately 4 weeks post-procedure, both cohorts will then undergo a post-intervention
clinical assessment. Finally, both cohorts will undergo a post-intervention fMRI of their
brain.