Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate whether statins have any influence on cytochrome P450 (CYP) 3A4 enzyme activity using a probe drug midazolam.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hamamatsu University
• Treatments: Atorvastatin; Atorvastatin Calcium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Midazolam; Pitavastatin; Simvastatin

Criteria

Inclusion Criteria:

• Volunteers in good health according to their medical history, a physical examination and standard laboratory tests

Exclusion Criteria:

• Subjects who have been using any continuous medication or herbal supplements.