Effects of Sleep Quality on Melatonin Levels and Inflammatory Response After Major Abdominal Surgery
Status:
Unknown status
Trial end date:
2017-07-01
Target enrollment:
Participant gender:
Summary
Endogenous melatonin is produced by the pineal gland at night under normal conditions and
regulates the sleep-wake cycle. Artificial light administered at night suppresses melatonin
production and sleep disturbances are accompanied by abnormal melatonin secretion such as
phase delay. Therefore, dramatic disturbances of endogenous rhythms in intensive care unit
patients have remarkable effects on melatonin production. In addition to its physiological
roles in regulating sleep patterns, melatonin has been demonstrated to provide
antiinflammatory effects in experimental models. Although some previous studies have
investigated the circadian pattern of melatonin in intensive care unit patients, the
investigators think that the present study is the first one that will assess the effects of
controlling noise and light on melatonin and inflammatory response after major abdominal
surgery.