Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain
function and structure induced by long-term opposite-sex steroid hormone administration in
transsexual subjects. Our aim is 1. to prove the influence of high-dose, long-term
opposite-sex steroid hormone treatment on functional brain response in transsexuals. 2. to
investigate the influence of hormone treatment on resting state functional connectivity and
brain morphology. 3. to investigate differences between transsexuals and healthy control
subjects in brain function and functional connectivity, brain morphology and structural
connectivity. In this longitudinal study, transsexuals and healthy control subjects will
undergo three 7 Tesla ultrahigh-field MRI scan sessions: 1. baseline (before hormone
treatment), 2. after 4 weeks of treatment and 3. after 4 months of treatment.