Effects of Seven Day Prucalopride Administration in Healthy Volunteers
Status:
Completed
Trial end date:
2019-05-17
Target enrollment:
Participant gender:
Summary
This study will investigate whether seven days administration of the serotonin receptor
subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and neural
activity in healthy volunteers, compared to placebo administration. Using an experimental
medicine approach, the effects of prucalopride on cognitive biomarkers of antidepressant
action will be characterised. In a double-blind design, participants will be randomised to
receive seven days administration of either prucalopride (1mg daily) or placebo. All
participants will come for a Screening visit, Research Visit One (including an MRI scan) and
Research Visit Two (including measures of emotional processing and non-emotional cognition).
The primary study hypothesis is that seven-day prucalopride administration will have positive
effects on emotional processing and reward sensitivity. A secondary hypothesis is that
seven-day prucalopride administration will alter non-emotional cognition. Finally, the study
will test the hypothesis that seven day prucalopride administration will alter neural
activity during an emotional faces task and a memory task.