Effects of 'Seroquel-XR' on the Improvement of Neurocognitive Function in People At-risk Mental States(ARMS)
Status:
Unknown status
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to assess the effects of 'Seroquel-XR' on the verbal
learning ability in people with at-risk mental state (ARMS) over a 12 week period. The verbal
learning ability will be indexed by delayed free recall score of CVLT(California Verbal
learning Test), a standard neuropsychological verbal memory tests.
The secondary objective is to assess the effects of 'Seroquel-XR' on other cognitive function
and psychiatric symptoms including psychotic, anhedonic symptoms, and impulsivity. The
cognitive function abilities will be measured by standard neuropsychological tests as
follows;
- Working memory: verbal & spatial 2-back test
- Attention: Digit Span, 3-7 CPT(Continuous Performance Test)
- Executive function: WCST (Wisconsin Card Sorting Test)
- Visuo-spatial ability: Rey Complex Figure Task copy
- Visuomotor speed and planning: Trail making test A & B
- Verbal fluency: Controlled Oral Word Association Test(COWAT) The scales of psychiatric
symptoms which will be used are as follows;
- Psychotic symptoms: Scales of Prodromal scales (SOPS), Positive and negative syndrome
scale (PANSS)
- Anhedonia: Social Anhedonia Scale (SAS), Physical Anhedonia Scale (PAS)
- Social cognition: Ambiguous Intention Hostility Questionnaire (AIHQ)
- Impulsivity: Barrett Impulsivity Scale (BIS)