Effects of SNP of GnRH Receptor Genes in IVF Patients
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Gonadotropin-releasing hormone analogue (GnRH-a) "long protocol" is a protocol for pituitary
down-regulation in IVF. However, it is common in clinic that some patients are hypersensitive
to pituitary down-regulation and have pituitary oversuppression, resulting in prolonged
ovarian stimulation and increased consumption of exogenous gonadotropin(Gn). On the other
hand, some patients may have insufficient pituitary down-regulation, which can affect the
synchronization of ovarian follicles and consequently reduce the number of oocytes
retrievable and lower the pregnancy rate. The differences in responses to GnRH-a among
patients may be associated with the SNP of their GnRH receptor genes. It has been reported
that mutations in GnRH receptor genes could change their binding affinity to the ligands,
thus affecting the outcome of pituitary down-regulation. So far 20 non-synonymous mutations
on the GnRH receptor genes have been reported, which can affect the function of GnRH receptor
and are highly associated with disorders such as endometriosis and sexual precocity. However,
the correlation between the SNP of GnRH receptor genes and the outcome of pituitary
down-regulation in IVF has not been reported.
The purpose of this study is to analyze the correlation between single nucleotide
polymorphism (SNP) of GnRH receptor genes in infertile female patients and the extent of
pituitary down-regulation by short-acting GnRH-a long protocol, with the goal to achieve
individual down-regulation protocols based on the patients' SNP haplotypes of GnRH receptor
genes and to improve the success rate of assisted reproductive technology.