Overview

Effects of SGLT-2 Inhibition on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI in Patients With DM2

Status:
Unknown status

Trial end date:
2020-12-01

Target enrollment:

Participant gender:

Summary

There is an unmet need for Cardiovascular Disease risk reduction in patients with Type 2 Diabetes. In recent trials there has been promising findings of more effective glucose management and reductions in overall CVD events and hospitalization for heart failure with SGLT-2 inhibition. Using the capability of cardiac MRI with T1- and T2-mapping in assessments of myocardial fibrosis and inflammation, the investigators propose to conduct a clinical trial to investigate the effects of SGLT-2 inhibition with dapagliflozin on myocardial fibrosis and inflammation as assessed by cardiac MRI with T1- and T2-mapping in patients with type-2 diabetes. Over approximately 12 months subjects will have 6 clinical visits at the investigators research clinic. During this time subjects will be randomized to receive either active 10mg dapagliflozin or a matching placebo. 2 MRI scans at one of the two UW research imaging centers will take place. One at randomization and the second scan will occur approximately 12 months after the first scan.

Phase:

Phase 4

Details

Lead Sponsor:

University of Washington

Collaborator:

AstraZeneca

Treatments:

Dapagliflozin