Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Treatments: Rosiglitazone

Criteria

Inclusion Criteria:

• Good general health

• Aged 10 to 18 yrs (females: Tanner stage II-V;and males:testes size>6ml)

• IGT based on 2-hr plasma glucose>140mg/dl and <200mg/dl during an OGTT.

Exclusion Criteria:

• Baseline creatinine>1.0mg

• AST and ALT>2.5 ULN

• Anemia (Hct<30)

• Pregnancy (females must have a negative urine pregnancy test during the study)

• Cardiac or pulmonary or other significant chronic illness

• Plans to increase the frequency or intensity of a regular exercise program

• Psychiatric disorder or substance abuse of anorexic agents.