Effects of Rosiglitazone and Metformin on Metabolism in Type 2 Diabetes
Status:
Completed
Trial end date:
2001-12-01
Target enrollment:
Participant gender:
Summary
The objectives of this study are to compare the effects of rosiglitazone and metformin on
insulin stimulated glucose uptake in subjects with type 2 diabetes. Whole body, and skeletal
muscle, heart and adipose tissue insulin stimulated glucose uptake is measured during
euglycemic hyperinsulinemic clamp and positron-emission tomography scanning before and 26
weeks after treatment in 48 newly diagnosed subjects with type 2 diabetes. Subjects will be
randomized to receive either rosiglitazone or metformin or placebo, according to a simple
randomization procedure with double blinding.