Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals
Status:
Completed
Trial end date:
2017-07-25
Target enrollment:
Participant gender:
Summary
Background:
- Roflumilast is a drug used to treat chronic obstructive pulmonary disease (COPD). It is
designed to help reduce lung inflammation. However, during testing, roflumilast also appeared
to reduce high blood sugar levels in people with COPD and type 2 diabetes. Other tests showed
that roflumilast also improved blood sugar levels in people who only had type 2 diabetes.
Researchers want to see how roflumilast affects insulin and blood sugar levels in overweight
or obese people who are not diabetic, but who have high blood sugar levels.
Objectives:
- To see how well roflumilast improves blood sugar and insulin levels in prediabetic
overweight or obese individuals.
Eligibility:
- Individuals between 30 to 65 years old who are overweight or obese (body mass index of 24.9
to 39.9 kg/m2) and have elevated blood sugar levels.
Design:
- This study will last approximately 8 weeks. Participants will have approximately five
study visits over about 7 weeks. Two of these visits will be overnight inpatient stays.
- Participants will be screened with a physical exam and medical history. Blood and urine
samples will be collected. They will also have a 3-day diet and exercise assessment with
a dietitian.
- In Week 1, participants will have a special diet for 2 days to keep their regular
weight. They will then have a 2-day inpatient stay. During their stay, they will have
multiple tests, including blood sugar tests and full body scans. They may provide a fat
and muscle tissue biopsy sample. They will then receive the study drug to take during
the study.
- In Week 2, participants will repeat the diet study from the screening visit. They will
receive a different dose of the study drug.
- In Week 3, participants will review their diet results and have blood and urine tests.
- In Week 5, participants will repeat the diet and exercise study from the screening
visit.
- In Week 6, participants will repeat the inpatient studies and tests from Week 1.
In the last week, participants will have a final follow-up visit.