Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients

• Status: Completed
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fondazione Poliambulanza Istituto Ospedaliero
• Treatments: Remifentanil

Criteria

Inclusion Criteria:

• pressure support ventilation or CPAP

• respiratory rate > 35.min-1

• respiratory rate/tidal volume > 105

Exclusion Criteria:

• vasoactive agents (dopamine lower than 5 mcg.kg-1.min-1 is not considered as vasoactive agent)

• body temperature > 38 °C

• Glasgow Coma Scale < 9

• FIO2 > 0.6

• PEEP > 10 cmH2O

• pH < 7.30