Effects of Ranolazine and Exercise on Daily Physical Activity Trial
Status:
Completed
Trial end date:
2016-10-10
Target enrollment:
Participant gender:
Summary
The primary objective is to assess whether the increased angina threshold on ranolazine and
subsequent higher training intensity will result in improved exercise tolerance and oxygen
consumption; and greater than that observed with exercise training on placebo. The study team
anticipates the chronic exercise improvements with ranolazine will be incrementally higher
than the acute effects provided by ranolazine alone and demonstrated in previous trials. Key
secondary objectives include the acute ranolazine and chronic exercise plus ranolazine
effects on total daily energy expenditure (TDEE) and angina-related quality of life.