Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Status:
Completed
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive
inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
Moreover, it was shown that the effects of beta-adrenergic stimulation were potentiated.
Thus, it might be possible to save catecholamines in patients with severe heart failure or
cardiogenic shock. This study was designed to test the hemodynamic effects of pyruvate
administered into a coronary artery in addition to intra-aortic balloon pump counterpulsation
in patients with severe heart failure or in patients with acute myocardial infarction and
cardiogenic shock after having performed percutaneous coronary intervention. A pronounced
improvement in hemodynamics is expected to occur.