Effects of Preoperative Correction of Anemia With Intravenously Iron in Colorectal Cancer Patients.
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to examine the effects of anemia correction with intravenous
administered iron on clinical outcomes and the immune response on the tumor in patients with
planned colonic- or rectal cancer surgery.
The study will be performed as a retrospective propensity score-matched cohort study with an
examination of immune response in tumor and clinical outcomes, between patients with anemia
without correction with iron(III)isomaltoside, non-anemic patients, and anemic patients
treated with iron(III)isomaltoside prior to surgery. Propensity score matching will ensure
identification of controls from a pool of patients treated at the Department of Surgery,
Zealand University Hospital. The two control groups will be: an anemic historical control
group (group 1), and a non-anemic concurrent control group (group 2). Group 3 will be the
treatment group, with patients with anemia and treated with iron(III)isomaltoside.
The study period of cases undergoing i.v. treatment will be 1st of February 2017 to 31st of
October 2019 with approximately 70 cases included