Effects of Pregabalin on Pain After Total Knee Arthroplasty
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Total knee arthroplasty can cause severe postoperative pain, and patients typically receive
oral opioid analgesics for over 2 weeks. Side effects of pain management may impair
participation in physical therapy and diminish patient satisfaction. Anecdotally, it seems
that pregabalin is very helpful to patients after total knee arthroplasty. However,
pregabalin can have side effects. It is not clear how much pregabalin to prescribe. Low doses
may not be effective, but use of high doses may increase the incidence and severity of side
effects.The purpose of this study is to determine which dosage of pregabalin is the most
effective at reducing pain after knee surgery.