Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears
Status:
Recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
A potential long-term consequence of anterior cruciate ligament injuries is the development
of post-traumatic osteoarthritis in the years following injury. There are no curative
treatments for osteoarthritis, increasing the importance of minimizing the occurrence of
post-traumatic osteoarthritis following anterior cruciate ligament injuries. Current
literature has begun to indicate that biochemical changes in the knee joint cartilage, such
as chondrocyte death, following injury can contribute to the development of post-traumatic
osteoarthritis.
The main objective of this study is to determine if an early intervention of joint aspiration
and platelet rich plasma injection will positively affect the biomarkers representative of
chondral degeneration in patients with anterior cruciate ligament injuries. We hypothesize
that the intervention will reduce the volume of inflammatory and chondrodegenerative
biomarkers following anterior cruciate ligament injury.