Effects of Phenylephrine on Cardiac Preload

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

In patients under general anesthesia, episodes of hypotension are often treated with phenylephrine. The effect of phenylephrine is conventionally attributed to afterload increase.

The aim of the study is to describe the time course of the effects of phenylephrine on the cardiac preload and cardiac output, and to evaluate whether phenylephrine, as an exclusive alpha-mimetic, could be beneficial for preload optimisation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Algemeen Ziekenhuis Maria Middelares
• Treatments: Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Adult

• necessity for arterial blood pressure monitoring

• necessity for central venous blood pressure monitoring

Exclusion Criteria:

• unwilling or unable to grant written informed consent

• cardiac arrythmia

• contra-indication for phenylephrine

• contra-indications for atropine

• contra-indication for Total Intravenous Anesthesia