Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
Open nephrectomy is one of the most common surgical procedures in urologic practice. Pain
after surgery remains a significant clinical problem as it impairs recovery adversely and may
lead to the transition to chronic pain. The open approach represents a major physical trauma
including postoperative pain and discomfort in the convalescence period. Adequate control of
postoperative pain facilitates earlier mobilization and rehabilitation. Patient-controlled
analgesia (PCA) is effective to treat pain at rest, but seems to be inadequate for dynamic
analgesia and may also elicit side effects that may delay hospital discharge. Preventing
early and late postsurgical pain is an important challenge for anesthesiologists and
surgeons.
Ketamine (N-Methyl-D-Aspartate receptor antagonist) and lidocaine (sodium channel blocker)
are popular analgesic adjuvants for improving perioperative pain management. The
investigators designed this double-blind, placebo controlled study to test and compare the
preventive effects of perioperative intravenous ketamine and lidocaine on early and chronic
pain after elective open nephrectomy.
The investigators propose a double-blind placebo-controlled study of patients undergoing
elective open nephrectomy. All patients will receive normal "patient-controlled analgesia
morphine" in addition to study drugs or placebo. Research will be conducted at Charles
Nicolle teaching hospital.