Effects of Perampanel on Neurophysiology Test Perimeters
Status:
Recruiting
Trial end date:
2023-03-17
Target enrollment:
Participant gender:
Summary
This is a study to evaluate the effects of perampanel, a FDA approved drug for epilepsy, on
commonly performed neurophysiology tests: electroencephalogram (EEG), somatosensory evoked
potential (SEP), brainstem auditory evoked potential (BAEP), and visual evoked potential
(VEP). Many other drugs used in the treatment of epilepsy have been shown to affect the
results of these test but no one has yet examined if perampanel affects these tests. The
investigators plan to recruit 12 healthy normal male subjects. All subjects will have VEP,
SSEP, EEG, and BAER performed before and 1 hour (when Cmax is reached) after receiving 6mg of
oral perampanel. Subjects will also receive a blood draw 1 hour after ingestion of perampanel
for serum perampanel level. In a previous study done at another institution, healthy
volunteers have tolerated a single dose of perampanel at 6 mg quite well. There is no placebo
nor randomization. Subject's participation concludes after completion of post-perampanel
ingestion neurophysiology tests.