Effects of Paroxetine on Cardiovascular Function in Septic Patients
Status:
Active, not recruiting
Trial end date:
2024-02-15
Target enrollment:
Participant gender:
Summary
It is known that septic shock is characterized by arterial hypotension, decreased peripheral
vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important
mediator of this organ dysfunction. Data in the literature have shown that hyporeactivity to
catecholamines is associated with a decrease in the density of α and ß receptors in the aorta
and heart, respectively, as well as an increase in GRK2 levels and that NO contributes to the
increase of this kinase in sepsis .
Based on this, it is hypothesized that cardiac dysfunction and decreased peripheral vascular
resistance observed in sepsis may result from an increase in GRK2 activity and/or expression
and its inhibition may be a relevant therapeutic target in septic shock patients. Based on
this line, a measurable clinical benefit of paroxetine through the regulation of GRK2
expression in patients with septic shock is postulated.
Phase:
Phase 2
Details
Lead Sponsor:
Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude