Effects of Oxytocin on Cognitive and Reactive Fear
Status:
Recruiting
Trial end date:
2021-05-01
Target enrollment:
Participant gender:
Summary
The study examines the (sub)regional specificity of anxiolytic oxytocin (OXT) effects on
emotional face processing and reactive and cognitive fear. Preliminary data indicate that the
Receptor for Advanced Glycation End Products (RAGE) may regulate oxytocin transport into the
brain. Thus, the study aims to replicate previous observations of oxytocin effects on the
processing of fearful faces in the centro-medial amygdala and to assess whether a RAGE
polymorphism (-374 T/A: rs1800624; TT vs. TA/AA), that has been shown to alter
transcriptional activity, modulates anxiolytic OXT effects.