Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
Chronic postoperative pain is one of the common perioperative complications, which seriously
affects the prognosis of patients. Currently, no specific perioperative pain management
strategy has been found to be effective in preventing and treating chronic postoperative pain
in patients undergoing spinal surgery. At present, oxycodone has been widely recognized in
different surgical populations for the control of acute postoperative pain, but its
contribution to chronic postoperative pain remains unknown. Meanwhile, whether pregabalin can
reduce the occurrence of chronic postoperative pain remains controversial, and whether the
combination of the two drugs can control the occurrence of chronic postoperative pain in a
more comprehensive way remains unknown. Therefore, we intend to conduct this
randomized-controlled, factorial design study to determine the efficacy and safety of
oxycodone combined with pregabalin in the treatment of chronic postoperative pain in patients
undergoing spinal surgery.