Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal Anesthesia
Status:
Completed
Trial end date:
2017-12-30
Target enrollment:
Participant gender:
Summary
BACKGROUND:
Spinal anesthesia (SA) induced maternal hypotension is the most frequent and troublesome
complication in cesarean section (CS), compromising both maternal and neonatal well-being.
Many strategies have been used to prevent its occurrence but no single technique has been
confirmed to be completely effective. the investigators hypothesized that ondansetron, a
serotonin-receptor-antagonist, could have beneficial effects on maternal hemodynamics during
CS under SA.
METHODS:
In this prospective double-blind placebo-controlled study, one hundred healthy parturients
were randomized to receive either 8 mg of intravenous ondansetron (group O) or the same
volume of saline (group S), 5 minutes prior to the induction of SA. All women received a
coloading volume of 500 ml of saline. Maternal hemodynamics: blood pressure, heart rate and
cardiac output (CO) were measured with a non-invasive device based on pulse wave transit
time: the esCCO device Nihon Kohden hemodynamic monitor. Ephedrine was administered to treat
hypotension (systolic blood pressure less than 80% of baseline).