Effects of Nitric Oxide on the Endothelium During Hemolysis.
Status:
Recruiting
Trial end date:
2022-10-30
Target enrollment:
Participant gender:
Summary
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric
Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical
Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to
receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery.
This ancillary study aims to assess the effects of Nitric Oxide on vascular responsiveness
and on endothelial function during hemolysis in patients with pre-operative endothelial
dysfunction undergoing cardiac surgery requiring prolonged cardiopulmonary bypass.
Phase:
Phase 2
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborators:
Jennifer En-Sian Ho M.D., Massachusetts General Hospital Marrazzo, Francesco, M.D., Massachusetts General Hospital Naomi M Hamburg, M.D., Boston University Spina, Stefano, M.D., Massachusetts General Hospital Zadek, Francesco, M.D., Massachusetts General Hospital