Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.
Status:
Completed
Trial end date:
2006-11-01
Target enrollment:
Participant gender:
Summary
Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular,
respiratory and metabolic features as weel as in exercise performance similar, for some
aspects, to those observed in chronic heart failure. Exposure to high altitude hypoxia
represents a suitable model to assess different treatments proposed for this pathological
condition. Our aim was to evaluate the impact of two different third-generation beta-blockers
used in heart failure (carvedilol and nebivolol) on cardiovascular, respiratory, metabolic
profile and on exercise performance at high altitude.