Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.

• Status: Completed
• Trial end date: 2012-01-01

Summary

The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and naloxone-3-glucuronide after oral administration of methylnaltrexone and naloxone.

• Phase: Phase 1

Details

• Lead Sponsor: University Medicine Greifswald
• Treatments: Antidiarrheals; Loperamide; Methylnaltrexone; Naloxone; Naltrexone; Sulfasalazine