Effects of Metformin and Fish Oil on Treatment With Clozapine
Status:
Terminated
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
One purpose of this study is to test whether adding metformin will limit some of the unwanted
effects of clozapine, compared to not adding metformin. Metformin is a medication that is
approved by the United States Food and Drug Administration (FDA) for the treatment of type-2
diabetes. Studies have found that people with type-2 diabetes often lose some weight when
they take metformin, however the FDA has not approved metformin for weight loss, so for this
study the use of metformin is investigational. This study will test whether metformin can
help people with schizophrenia or schizoaffective disorders lose weight.
Another purpose of this study is to test whether adding fish oil will improve the benefit of
clozapine and/or limit some of the unwanted effects of clozapine, compared to not adding fish
oil. Fish oil is a medication used to reduce levels of some fats (triglycerides) in blood.
Some studies have found that adding fish oil reduces psychosis (voices, suspiciousness).
However the FDA has not approved fish oil for reducing psychosis, so for this study the use
of fish oil is investigational. This study will test whether fish oil can help people with
schizophrenia or schizoaffective disorders have less psychosis. Fish oil is not an
antipsychotic medication.