Effects of Mesna on Homocysteine in Kidney Failure

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to examine the effect of a drug called mesna on the removal of homocysteine from blood during dialysis. Homocysteine is an amino acid (protein building block) found in the blood of all people, however it is considerably elevated in dialysis patients. People with increased levels of homocysteine in their blood are at increased risk of developing plaque buildup in their arteries and other related problems such as heart attack and stroke. This study will determine if mesna can improve the rate of homocysteine removal from blood during dialysis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Collaborator: Canadian Institutes of Health Research (CIHR)
• Treatments: Mesna

Criteria

Inclusion Criteria:

• Patients with end-stage renal disease who have received hemodialysis thrice weekly for at least 90 days

• Serum albumin > 30 g/L.

Exclusion Criteria:

• Patients who refuse to sign a letter of informed consent

• Women who are or are trying to become pregnant or are breast-feeding.