Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
Status:
Completed
Trial end date:
2009-09-01
Target enrollment:
Participant gender:
Summary
In heavy marijuana smokers, opioid receptor blockade increases the subjective and
cardiovascular effects of marijuana. The current study was designed to clarify
opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function
for marijuana-elicited effects in heavy marijuana smokers. For this within-subject,
double-blind study, a marijuana smoking procedure was designed to characterize a
dose-response relationship for marijuana's subjective and cardiovascular effects under
blinded conditions.
Phase:
Phase 2
Details
Lead Sponsor:
New York State Psychiatric Institute
Collaborators:
National Institute on Drug Abuse (NIDA) Research Foundation for Mental Hygiene, Inc.