Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline
on that inflammation are elucidated in this project. NF-kappa B-dependent pathway and
acetylation status of nuclear histones are to be studied.Design: controlled, prospective and
randomized study with or without theophylline, a potent HDAC activator.Objectives: 1) To
determine NF-kB activation, histone deacetylase (HDAC) and histone acetyl-transferase (HAT)
activity in sputum macrophages and blood monocytes during an episode of exacerbation and 3
months later, once stability is achieved. To correlate these measurements with inflammatory
and oxidative stress markers and with pulmonary function and clinical variables. 2) To assess
the effect of theophylline on previous molecular, functional and clinical data. Method: 25
patients with COPD will be recruited during an episode of exacerbation requiring
hospitalization. NF-kB activation, HDAC and HAT activity, markers of inflammation and
oxidative stress will be determined with specific assays. These determinations will be
repeated once the patient is stable and compared with smokers and non smoker controls with
normal lung function
Phase:
N/A
Details
Lead Sponsor:
Hospital Universitari Son Dureta
Collaborators:
Fondo de Investigación Sanitaria (FIS) Sociedad Española de Neumología y Cirugía Torácica