Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
Status:
Completed
Trial end date:
2006-07-01
Target enrollment:
Participant gender:
Summary
Angiotensin type-1 receptor (AT1R) blockers (ARBs) have been recognized recently as
regulators of glucose and lipid metabolism in adipocytes and adipose tissue.Moreover
telmisartan and irbesartan have been recognized recently as regulators of glucose metabolism.
For ARB losartan, the results were controversial. To confirm its effect on glucose
metabolism, we designed and performed a prospective, randomized and controlled study in
subjects with type 2 diabetes and nephropathy.