Effects of Long Term Macrolide Antibiotic Therapy in Patients With COPD

• Status: Unknown status
• Trial end date: 2006-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether long term treatment with oral erythromycin is effective in the treatment of subjects with Chronic Obstructive Pulmonary Disease (COPD) by reducing the number of exacerbations and the degree of airway inflammation.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Royal Free and University College Medical School
• Treatments: Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate

Criteria

Inclusion Criteria:

• Clinical Diagnosis of COPD

• Clinically stable for 6 weeks

• Able to Swallow Tablets

Exclusion Criteria:

• Clinically significant respiratory disease other than COPD

• Women of child bearing age

• Patients receiving existing Medication which may interact adversely with trial drug

• History of clinically significant liver disease