Effects of Local Anaesthetic Infusion Rates on Nerve Block Duration

• Status: Terminated
• Trial end date: 2016-12-09
• Target enrollment: 0
• Participant gender: All

Summary

This trial is a part of the project: 'A novel technique for reliable, precise and safe postoperative pain management' (project no. 65-2014-3).

The purpose of the trial is to investigate the effects of changing peri-neural infusion rates of ropivacaine 0.2% on the duration of nerve block.

Intervention:

Two intervention-days. Each day a peri-neural infusion of a fixed volume of ropivacaine 0.2% is to be infused in one of five infusion rates, using a peri-neural catheter.

Intervention day 1: Focus on the common peroneal nerve. Intervention day 2: Focus on the sciatic nerve.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nordsjaellands Hospital
• Treatments: Anesthetics; Anesthetics, Local; Ropivacaine

Criteria

Inclusion criteria

1. Male or female ≥18, ≤ 64 years of age

2. ASA classification17 ≤ II

Exclusion criteria

1. BMI ≤ 18 or ≥ 30 kg/m2

2. Body weight ≤ 37.5 kg

3. Former surgery to the lower extremities

4. Peripheral nerve disease, including polyneuropathy and diabetes

5. Allergy to local anaesthetics

6. Pregnancy or breastfeeding

7. Enrolment in other investigational drug studies or recent clinical trials that may interfere with this study

8. Habitual use of any kind of analgesic treatment

9. Anatomic abnormalities preventing successful US-guided Certa Catheter™ insertion.