Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a
controversy in effect of subclinical hypothyroidism on cardiovascular diseases. We aim to
estimate the relation between subclinical hypothyroidism and endothelial dysfunction and the
effects of levothyroxine therapy on it. Patients with confirmed subclinical hypothyroidism by
lab results will be randomized to two groups of treatment with one daily dose of 100 mg
Levothyroxine or placebo. The flow-mediated dilation and intima media thickness are evaluated
before and after the study.