Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism
Status:
Withdrawn
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Renal and cardiovascular effects of subclinical hypothyroidism, defined by a high TSH and
normal T4 are less known and the indications for treatment of subclinical hypothyroidism are
subject to controversies.
The investigators propose to assess whether the hormone replacement for subclinical
hypothyroidism in patients with chronic kidney disease is beneficial for hemodynamic and
renal functions and which mechanisms are involved.
Isotopic measurements of glomerular filtration and renal blood flow and an hemodynamic
evaluation by transthoracic echocardiography and flow-mediated vasodilation will be carried
out before and 6 months after substitution.