Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism

• Status: Unknown status
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Université de Sherbrooke

Criteria

Inclusion Criteria:

• Biochemical diagnosis of subclinical hypothyroidism (TSH between 3.5 and 10 with a normal T4)

• Systolic heart failure with New-York Heart Association (NYHA) class II or III

• Left ventricular ejection fraction under 40%

• Stable heart failure for the past 3 months (no IV furosemide or hospital admission)

• Beta-blockers and ACE inhibitors titrated to the maximum tolerated dose

Exclusion Criteria:

• Isolated diastolic heart failure

• Awaiting cardiac resynchronisation therapy

• Impossibility to perform the 6 minutes walk test

• Active cancer / Life expectancy under 18 months

• Treatment with amiodarone