Effects of Levosimendan in Acute Kidney Injury After Cardiac Surgery
Status:
Completed
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Acute kidney injury (AKI) is a common complication after cardiac surgery. Mismatch in renal
oxygen demand-supply may be an important pathogenetic factor. Levosimendan has been shown to
improve renal blood flow, glomerular filtration rate and renal oxygenation in healthy
controls after cardiac surgery.
In order to investigate the effect of levosimendan in patients with AKI after cardiac
surgery, the investigators plan a randomized placebo controlled trial. 30 patients will
receive levosimendan or placebo. Renal blood flow and filtration fraction will be measured
using infusion clearance technique of para-aminohippuric acid and Chromium
ethylenediaminetetraacetic acid (Cr-EDTA) respectively.