Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Status:
Completed
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent
muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a
promising strategy to prevent or treat skeletal muscle wasting. Therefore, our aim is to
investigate the effect of 3HHB intake on muscle wasting and its adverse consequences during a
period of caloric restriction in lean females. In addition, we compare the effects of 3HHB
intake with a high protein diet, which is currently considered as the best strategy to
minimize lean loss during hypo-energetic periods. To end, we aim to investigate the
synergistic effects of the intake of 3HHB in combination with a high protein diet.