Effects of Ketamine on Eye Movements, Perception and Brain Function
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
In this study, the investigators examine the effects of low-dose ketamine on different
oculomotor, perceptual and cognitive functions. They also examine effects on concurrent brain
activity using blood oxygen level dependent (BOLD) functional magnetic resonance imaging
(fMRI). A sample of N=25 healthy, male participants is required to complete the study. The
design is within-subjects, placebo-controlled, double-blind and cross-over. A targeted
ketamine level in plasma of 100ng/ml is applied. It is hypothesised that ketamine, compared
to placebo, will lead to changes in task performance and brain activity similar to those
observed in patients with schizophrenia.