Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
The magnesium sulfate and lidocaine have been increasingly used alone or in combination
during anesthesia procedure to meet various objectives, such as reduction of pain, use of
smaller anesthetic doses and stabilization of hemodynamic parameters.
These medicines are often used in combination with neuromuscular blocking agents, which may
contribute to the occurrence of residual block in some patients after anesthetic procedures.
It was estimated that only 1-3 % of patients with residual block developing clinically
apparent events. In a small proportion of patients, the consequences of residual blockade are
very serious and even lethal. It is estimated that 40 % of patients with muscle paralysis
come to the post-anesthesia care unit (PACU).
Considering that: (a) magnesium sulfate and lidocaine are showing an increasing number of
applications in various areas of medicine, (b) these medications stand out for their
properties analgesic, anti-inflammatory, anti-arrhythmic, neuroprotective and capable of
reducing the demand of anesthetics and opioids, (c) magnesium sulfate as lidocaine has been
important part of the therapeutic arsenal to control a large number of diseases (d) the
patient surgical surgery or potentially have benefited in particular from its effects, (and)
these drugs have been used routinely in many medical services as well as adjuvants in
anesthesia, (f) previous studies have shown that magnesium sulfate is able to prolong the
duration of neuromuscular blockade by different types of muscle relaxants, with controversies
about its effect on latency (g) the effect of lidocaine on the action of muscle relaxants in
current literature have shown great controversy and (h) do not exist in the literature
studies involving both drugs; the investigators aimed to investigate the effects of magnesium
sulphate infused alone or associated with lidocaine on the neuromuscular blockade promoted by
cisatracurium, as well as evaluate its possible hemodynamic repercussions. For this purpose
the SM was infused in bolus, prior to tracheal intubation and continuously during the
maintenance of general anesthesia; the Lidocaine, when associated and the Isotonic Solution
were used in the same way and timeline as SM. As secondary objectives it has been proposed to
evaluate if the Lidocaine with Magnesium Sulfate would be able to interfere with the
hemodynamic stability of the patients in the study.