Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
Status:
Unknown status
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to measure the variations of serum and urinary hepcidin levels
following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is
a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular
efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate
hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be
postulated that erythropoietin could modulate hepcidin synthesis.