Overview

Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance

Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
0
Participant gender:
All
Summary
Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle biopsies are performed. The goal of the study is to determine whether the lipotoxiciy of impaired glucose tolerance is ameliorated by pioglitazone.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
US Department of Veterans Affairs
VA Office of Research and Development
Treatments:
Metformin
Pioglitazone
Criteria
Inclusion Criteria:

- Impaired glucose tolerance

- Body mass index (BMI) of 28-38

Exclusion Criteria:

- Heart disease

- Renal disease

- Liver disease