Overview
Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
Status:
Completed
Completed
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Regional Hospital HolstebroTreatments:
Nitric Oxide
omega-N-Methylarginine
Criteria
Inclusion Criteria:- Essential hypertension (blood pressure > 140/90) with no signs of secondary
hypertension
- P-creatinine < 200 µmol/L
Exclusion Criteria:
- Anamnestic or clinical signs of heart disease, renal disease, liver disease,
neoplastic disease, anemia or cerebro-vascular insult
- Medication except antihypertensives
- Drug or alcohol abuse
- Pregnancy