Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
Status:
Not yet recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary
shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far,
hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is
a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery
resistance by selectively dilating pulmonary artery. In this prospective, randomized, double
blind study, the investigator is planning to investigate the effects of iloprost on
respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.